Nerve growth factor: role in growth, differentiation and controlling cancer cell development
نویسندگان
چکیده
منابع مشابه
Nerve growth factor: role in growth, differentiation and controlling cancer cell development
Recent progress in the Nerve Growth Factor (NGF) research has shown that this factor acts not only outside its classical domain of the peripheral and central nervous system, but also on non-neuronal and cancer cells. This latter observation has led to divergent hypothesis about the role of NGF, its specific distribution pattern within the tissues and its implication in induction as well as prog...
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Nerve growth factor (NGF) is a neurotropic polypeptide necessary for the survival and growth of some central neurons, as well as sensory afferent and sympathetic neurons. Much is now known of the structural and functional characteristics of NGF, whose gene has recently been cloned. Since it is synthesized in largest amounts by the male mouse submandibular gland, its role exclusively in nerve gr...
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One of the major challenges for cancer therapeutics is the resistance of many tumor cells to induction of cell death due to pro-survival signaling in the cancer cells. Here we review the growing literature which shows that neurotrophins contribute to pro-survival signaling in many different types of cancer. In particular, nerve growth factor, the archetypal neurotrophin, has been shown to play ...
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ژورنال
عنوان ژورنال: Journal of Experimental & Clinical Cancer Research
سال: 2016
ISSN: 1756-9966
DOI: 10.1186/s13046-016-0395-y